Abstracto

Lignans from the Leaves of Meliosma lepidota ssp. squamulata and their Biological Activity toward Leishmania major

Mio Iwami, Susumu Kawakami, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka*, Tsutomu Mizuta, Takakazu Shinzato

From the leaves of Meliosma lepidota ssp. squamulata, one new sesamintype lignan was isolated. Its structure was first elucidated by spectroscopic investigation and then finally determined by X-ray crystallographic analysis. The anti-Leishmania activity of the new lignan and related ones, (+)-aptosimon, (+)-sesamin and (+)-paulownin, isolated from this plant was evaluated.