Ping Yang1, Zhe Li2, Tye Kian Deng3, Tong Lu4, Yuyi Chen3, Zonglin He5, Juan Zhou3, Xiaomin Xiao3*
Objective : To investigate the effect of orally supplemented probiotics on the placental microbiota at term and provide potential evidence for the clinical management of pregnant women.
Methods: A population-based cohort of samples was collected from 37 healthy nulliparous pregnant women who underwent systemic screening. Pregnant women were randomly divided into a probiotic group and a control group. We collected placenta samples during spontaneous delivery at term. Placental samples were taken for microbiome analysis with 16S rRNA amplicon sequencing of the V4 region.
Results: There were no significant differences between the two groups in clinical characteristics. The placental microbiota of normal vaginal delivery was composed of Bacteroides, Lactobacillus and Ralstonia. The relative abundance of Prevotella_9, Faecalibacterium and Escherichia_Shigella, etc., in the probiotic group was significantly higher than that in the control group (p<0.05). Probiotic supplementation might affect the network structure of placental microbiota.
Conclusion: The characteristics of the placental microbiome changed after probiotic supplementation and the interaction network structure tended to be looser. Probiotic supplementation may be useful to regulate the interaction network of the placental microbiome.
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