Abstracto

Fast Dissolving Tablets: A Big Turn in Pharmaceutical Industry

Sakshi Saxena and Nikku Yadav

Oral route of drug administration has been the most preferred one due to the seamlessly numerous advantages that it offers. Adding on to the existing benefits, researchers have smartly used the recent technology and advance knowledge to take oral drug delivery system to next level of patient convenience and compliance. Fast dissolving tablets (FDTs) are the output of this ongoing advancement in science. This novel concept addresses many patient needs from enhancing life cycle management to offering super convenient dosing, especially for pediatric, geriatric, and psychiatric patients for whom swallowing the conventional tablets and capsules was a trouble. This present report generates database on development and evaluation of FDTs from 2000-2016. Along with this, it is aimed at providing complete information of superdisintegrants and the techniques employed in preparation of FDTs studies in past 15 years. Sixty studies were taken into consideration. The findings suggest that majority of FDTs are formulated for NSAIDs, analgesics, GI drugs and cardiovascular including antihypertensive drugs and least for antidiabetic and anticancer drugs. Most of the studies (34 out of 42 studies) used crosspovidone at different concentrations (5% to 10% w/w). 36 out of 60 studies used direct compression (DC) technique for formulation of FDTs.