Abstracto

Anticancer Activity of Extract Derived From the Leaves of Careya Arborea on Rats

Ramesh HA and Dinesh B Shenoy

One of the largest causes of mortality worldwide is cancer. Increasing interest and research on herbal medicine have revealed its importance in treating many diseases including cancer. In the present study anticancer activity of the methanolic extract of leaves of Careya arborea Roxb was on DAL model in rats was evaluated. After inoculation of DAL cells into rats, treatment with Careya arborea Roxb extract (200 and 400 mg/kg) and standard drug 5-Fluorouracil (20 mg/kg) were continued for 9 days. Evaluation of the effect of drug response was made by the study of tumor growth response including increase in life span, study of hematological parameters, biochemical estimations, antioxidant assay of liver tissue and in vitro cytotoxicity. Experimental results revealed that Careya arborea Roxb extract possesses significant anticancer activity which may be due to its cytotoxicity and antioxidant properties. Further research is going on to find out the active principles of Careya arborea Roxb extract for its anti-cancer activity.