Abstracto

Novel Immune-Modulating Peptide to Counteract DNA Damage and Boost Tissue Repair: Advanced Machine Learning Confirmation Over Transcriptomes From 3,250 Patients

María Ribagorda1, Gutiérrez-Cazurro P1, Jordi Pérez-Cano1, Jessica E. Nuñez2, Carbache MF2, Joaquin Carballido Rodríguez3,4 , Castan Pablo1,5*

Peptides are endogenous protein building blocks that play a pivotal role in the metabolism activating numerous endogenous repair mechanisms. Some peptides span this role controlling putative processes such as the decrease of activity for oxidative enzymes and the upsurge of activity for antioxidant enzymes. In this work, we subject the activity of SH-Oligopeptide-85 SP peptide (Tectum11©) to deep functional analysis using a novel artificial Intelligence system, training it specifically with 3,250 patient transcriptomes from the worldwide reference database Gene Expression Omnibus© (National Centre for Biotechnology Information, NIH USA) to validate its mechanisms of action in penetrating inner tissue structures to decrease the oxidative stress and reduce both global DNA and telomeric damage through inflammatory pathways. Further evidence supporting the use of the SH-Oligopeptide-85 SP peptide (Tectum11©) in patients suffering acute and/ or chronic skin inflammatory skin diseases such as radiodermitis, pruritic skin lesions, xerosis and ichthyosis is also provided.