Abstracto

Effects of Rutin and Injection of Various Antioxidants on Experimental Acute Pancreatitis

Kayumov Khasan Yusupovich, Kuchkarova Lyubov Salijanovna , Safarova O’g’iloy Sirochovna

In this review article, recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced. Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis, translation to the clinic has thus far been disappointing. However, it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. The aim of this study is to investigate the effect of antioxidants, dihydroquercetin, rutin, and various combinations of the two flavonoids on αamylase and protease activities and the ability of the flavonoids to inhibit some pro-oxidants-induced lipid peroxidation in rat pancreas.