Abstracto

Spectrophotometric Method Development and Validation of Valacyclovir Hydrochloride in Bulk and Pharmaceutical Dosage Form

VMK Gowtam Potnuru, Krishna Reddy Y, Arjun CH, Prasanthi P, Ramya Krishna M, and Chandra Sekhar E

A simple, accurate, precise UV spectrophotometric method was developed in pure and pharmaceutical formulations for Valacyclovir hydrochloride. It is a antiviral drug. Valacyclovir hydrochloride exhibiting maximum absorbance at 255 nm in 0.1 M sulphuric acid and the method was validated for linearity, precision, sensitivity, and specificity. The drug obeyed linearity at concentration range of 4–12 μg/ml. The proposed method was validated statistically with significant high value of correlation coefficient 0.999. The percentage recovery value for Valacyclovir hydrochloride was in the range of 99.4 – 100.9 %. Therefore, the proposed method could be applied for the routine analysis of pharmaceutical dosage forms containing Valacyclovir hydrochloride.