Abstracto

Network Based Approach for Understanding the Chondrocyte Biology for Rheumatoid Arthritis

Snijesh. V.P, Sachidanand Singh

The major component of cartilage connective tissue, chondrocytes plays major role in Rheumatoid arthritis (RA),which is a chronic auto-immune disease of unknown etiology characterized by series of process such as inflammation, synovial hyperplasia and cartilage destruction leading to bone erosion. In the present work, role of chondrocytes which maintains the balance between synthesis and degradation of cartilage by osteoblast and osteoclast are focused. The key regulatory molecules in chondrocytes associated with pathophysiology of RA are extracted by integrating Biological network analysis and gene expression profiling data analysis. The expression data retrieved from gene expression omnibus included normal donor and diseased data set.By applying analytical and statistical measureshighly correlated differentially expressed genes were obtained.Clusteringof up and down networks resulted in three meaningful modular networks with seed genes ABO, AMPD3 and COA1. These seed genes were highly connected with the neighboring genes. So the biological analysis of modular network opens more ways for unraveling further more interactions to produce novel proteins related to RA.