Abstracto

Identification, Screening, and Application of Natural Peptides from Toad

Dihui Xu1, Shuangbing Deng1, Xiang Lv1, Rui Gan1, Yuyu Zhu1*, Jing Zhou1*, Hongyue Ma1,2*

Natural peptide drugs have good targeting properties and lower toxicity compared to small molecule drugs. A large number of animal-derived peptides have been gradually discovered over the past 60 years. These natural peptides, with potential biological activity, can be used to treat human diseases. In addition, some natural peptides possess species specificity, which can be used for quality control of peptide drugs, thereby improving the consistency and clinical safety of medications. In this mini review, we present the current strategies for identifying and screening natural peptides from toad, as well as their applications in quality control, species-based identification, and the discovery of new peptide leads.