Detection of Human Papillomavirus Type 16 Oncogen E7 in Surgical Materials from Russian Prostate Cancer Patients

Galina M Volgareva, Valeria D Ermilova, Alexander V Khachaturyan, Viktor V Tatarsky, Vsevolod B Matveev and Larisa S Pavlova

Prostate cancer (PC) is the second most common malignant tumor of men the world over. There is no clarification on causes of PC development yet. The long-discussed item of possible PC association with oncogenic human papillomaviruses (HPV) is still being disputable. The aim of the study was to test by PCR whether surgical materials from PC patients in Russia harbour E7 oncogene of HPV16, the main HPV type responsible for cervical cancer. Cryostate cuts of prostates excised in the course of radical prostatectomy from 17 PC patients were microdissected. HPV16 E7 was found in 7 patients including all those five cases for which DNA had been isolated from homogeneous sites of cancer cells. The results obtained seem to be significant for clarification of PC etiology as well as for development of preventive measures.